GLYCOMICS

Finding the sweet spots in your data

  • We provide a qualitative and quantitative overview of protein- and lipid-derived glycans in your samples. We focus on the entire glycan pool or on target glycoproteins or glycolipids.

  • We include the necessary sample preparation steps prior analysis, such as enzymatic glycan liberation and derivatization with a mass spectrometry-sensitive label.

  • We use hydrophilic interaction liquid chromatography (HILIC) with fluorescence detection and quadrupole time-of-flight (Q-TOF) mass spectrometry for unsurpassed resolving power and sensitivity.

  • We identify glycans using a glucose unit (GU) library supported with MS data and exoglycosidase sequencing to identify yet unknown species.

  • We follow a rigorous and established game plan┬áthat helps define the right questions and determine which data will provide the answers.

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A few examples of projects we have supported in the past

  • In-depth glycan profiling of exosomes in plasma and urine

  • Immunomodulation through different N-glycosylation profiles

  • Monitoring the impact of drugs on the sialylation degree of hepatocyte proteins