We provide a qualitative and quantitative overview of protein- and lipid-derived glycans in your samples. We focus on the entire glycan pool or on target glycoproteins or glycolipids.
We include the necessary sample preparation steps prior analysis, such as enzymatic glycan liberation and derivatization with a mass spectrometry-sensitive label.
We use hydrophilic interaction liquid chromatography (HILIC) with fluorescence detection and quadrupole time-of-flight (Q-TOF) mass spectrometry for unsurpassed resolving power and sensitivity.
We identify glycans using a glucose unit (GU) library supported with MS data and exoglycosidase sequencing to identify yet unknown species.
We follow a rigorous and established game plan that helps define the right questions and determine which data will provide the answers.
In-depth glycan profiling of exosomes in plasma and urine
Immunomodulation through different N-glycosylation profiles
Monitoring the impact of drugs on the sialylation degree of hepatocyte proteins
Copyright 2022 RIC group